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LiuYang Group, Institute of Agro-food Science and Technology, Chinese Academy of Agricultural Sciences
Research direction Research project Research findings Published papers International Cooperation Team members
1. Mycotoxin Formation Mechanism
 
    Build mycotoxins synthetic gene regulatory networks, to clarify the mechanism of formation and regulation of mycotoxins, by toxigenic fungi genomics, transcriptomics and metabolomics research,. Using metagenomics, ITS high-throughput sequencing technology, study structure and variation of fungal flora, revealing the formation mechanism of fungal flora. 
 
2. Mycotoxin Prevention and Control in Agricultural Products
    In agricultural cultivation, harvesting, storage and processing, to carry out mycotoxins inhibition, blocking, monitoring, early warning, detection technology research and product development, and demonstration; using genomics, biochemistry and mass spectrometry, analyze molecular mechanism of mycotoxins inhibition.
 
3. Detoxification of Mycotoxins in Food and Fodder
 
    In food and fodder production process, to carry out research and development of biological enzymes and bacteria preparation, removal of contaminated material sorting and development of biological products and equipment, such as adsorption. Using genomics, biochemistry and mass spectrometry, analyze biochemistry and molecular mechanism of degradation and removal of mycotoxins.
 
4. Survey of National Mycotoxins of Agricultural Products and Pollution Toxigenic Fungi
 
    Around cereals, oilseeds, fruits, nuts, spices, animal feed and other agricultural products, carry out mycotoxins and toxigenic fungi pollution surveys to collect 10,000 samples of agricultural products annually,  to get the basic data of agricultural products mycotoxins and toxigenic fungi pollution basic data, including the type of mycotoxin content and the type of toxin-producing fungi, distribution characteristics, toxigenic types.
 
5. Construction of China Strain Resource Library of Toxigenic Fungi, China Agricultural Products Mycotoxin Contamination Database, and China Agricultural Products Toxigenic Fungal Contamination Database 
 
    Based on national agricultural mycotoxins and toxigenic pollution database, collect census data and establish detailed, information-rich, open shared "China Strain Resource Library of Toxigenic Fungi", "China Agricultural Products Mycotoxin Contamination Database", and "China Agricultural Products Toxigenic Fungal Contamination Database". 
Project 1

Project Source: National Key Basic Research and Development Program (973)
Project Name: The main grain and oil products during storage mycotoxin formation mechanism and prevention foundation
Project Number: 2013CB127800
First Undertaker: Institute of Agro-food Science and Technology, Chinese Academy of Agricultural Sciences
Project Leader: Professor Liu Yang 
Project Description:
 
    Mycotoxins are secondary metabolites produced by fungi, has strong toxicity and carcinogenicity, can contaminate almost all types of food and forage farm, serious harm to human, animal health, mycotoxin contamination of agricultural products has become the world's attention hot food safety. Our mycotoxin contamination of grain and oil products by serious food losses caused about 31 million tons per year, of which the storage period loss of about 21 million tons, 67% of the total losses. Oils toxin strengthen prevention and control research products during storage fungi have become food security, food safety and safeguarding the interests of the urgent needs of the national economy in China.
 
    This project addresses significant demand "grain and oil products during storage mycotoxin prevention and control," the country, around the "flora occur during storage and toxin formation mechanism" and "Warning toxin during storage and Prevention Technology" two key scientific problems with contamination of China's major grain and oil products as wheat, corn, rice, peanut aflatoxin and Fusarium toxins for the study, the groups, individuals, cells, molecules of four levels, to carry out research in the following five topics: 1. mechanism of fungi occur during storage; 2 mycotoxin formation during storage mechanism; 3. Toxic fungal infestation during storage mechanism; 4. grain storage mycotoxins early warning monitoring infrastructure; 5. inhibition and removal of stored grain mycotoxins foundation .
 
    Through the implementation of this project will be constructed during storage of grain and oil products mycotoxin prevention and control system to provide a strong theoretical foundation and technical support, and promote the establishment with Chinese characteristics, prevention and control of mycotoxins discipline, cohesion, and develop a mycotoxin prevention and control of national innovation research team, enhancing our capacity for independent innovation and international influence mycotoxin prevention and control research for safety, food security and economic interests of food science and technology to provide strong support.


Project 2

Project Source: Public service sectors (agriculture) research and special
Project Name: Oils mycotoxins Control Technology
Project Number: 201203037
First Undertaker: Institute of Agro-food Science and Technology, Chinese Academy of Agricultural Sciences
Project Leader: Professor Wang Fengzhong
Project Description:
 
    Agricultural processing projects based Institute of Chinese Academy of Agricultural Sciences, the integration of the National Cereals, Oils and 8 mycotoxin contamination control technology research and promotion of the advantages of the unit, the use of modern biotechnology and agro-processing technologies, to carry wheat, corn, rice and peanuts and other oil crops in control and removal techniques planting, harvesting, storage and processing of mycotoxins (aflatoxins, Fusarium toxins), and in the cultivation of grain and oil processing enterprises and quality inspection departments demonstration. Through the implementation of the project, to effectively reduce mycotoxin contamination of grain and oil, grain and oil products to enhance the quality, improve the economic efficiency of farmers and processing enterprises, the purpose of promoting the healthy development of trade and export of grain and oil processing industry, grain and oil products, while achieving Oils impairment production, protect the health of consumers. And as the basis of this project, fostering an industry technology research team, train a number of grassroots skeleton staff.
 

Project 3
Project Source: Special focus on the basic work projects
Project Name: Processing of agricultural products and raw materials toxigenic fungal toxin contamination investigation
Project Number: 2013FY113400
First Undertaker: Institute of Agro-food Science and Technology, Chinese Academy of Agricultural Sciences
Project Leader: Professor Liu Yang
Project Description:
 
    Special focus on the basic work after the public welfare projects and 973 industry research and special projects of the research process where "national agricultural raw materials for the production of mycotoxins and their germs pollution investigation" (2013FY113400), hosted by the Institute of Agro Chinese Academy of Agricultural Sciences, is national Science and Technology Program is another major project in the field to get support. The project intends to cereals, oilseeds, fruits, nuts, spices, feed ingredients and other agricultural products processing of raw materials for the object, to carry out a nationwide survey to find out the national agricultural raw materials for toxigenic fungi and mycotoxins contamination, specifically China's major agricultural products processing feedstock type and extent of contamination of fungal toxins and toxigenic fungi species, distribution, content, establish a national agricultural raw materials for mycotoxins and toxigenic fungi and bacteria contamination database repository for conducting a comprehensive prevention and control of mycotoxins in agricultural research to provide important strain resources and systems on the basis of scientific data.
1. Detoxification of Mycotoxins in Food and Fodder
 
    Get domestic and foreign first reported aflatoxin, zearalenone, ochratoxin, degrading bacteria DON toxin reveals its degradation mechanism. Develope aflatoxin, zearalenone-degrading bacteria reagents. Get mycotoxins degrading enzyme by separation, purification and identification. Develope zearalenone mycotoxins degrading enzymes. Develope a moldy grain gravity separation equipment and moldy grain laser sorting equipment. Develope biological enzyme, microbial degradation, microbial adsorption, protein preparation, alkaline wet milling, wheat flour and other mycotoxins to removal technologies. Develope a series of supporting technical solutions for mycotoxin detoxification and feed grain and oil processing.

2. Toxicology Research

    Developed a moldy grain gravity separation equipment and moldy grain laser sorting equipment.

3. Processing Technique to Remove Mycotoxins

    Developed a wheat cleaning, wheat flour, protein preparation, alkalizing wet milling, microbiological removal mycotoxins adsorption processing technology more than 10, developed a series of supporting the removal of technical solutions for mycotoxins and feed grain and oil processing.

 
4. Mycotoxin Prevention and Control in Agricultural Products
 
    Develope three kinds of efficient inhibitor of mycotoxin and toxigenic fungi. This inhibitor reagent is safe, non-toxic, volatile, which can replace the currently used for storage of highly toxic, flammable fumigant phosphine. Develope a set of mycotoxin prevention treatment equipments. Develope inhibitor reagent and related control technology of aflatoxin and toxigenic fungi in cultivation of peanut and maize. Develope inhibitor reagent and related control technology of fusarium graminearum and the DON toxin in cultivation of wheat. 
 
5. Mycotoxin Formation Mechanism
 
    Clarify the molecular mechanism of non-toxigenic and high-toxigenic Aspergillus flavus. Discover and validate ochratoxin synthetic gene cluster and key genes.

6. Construction of China Strain Resource Library of Toxigenic Fungi
 
7. Construction of China Agricultural Products Mycotoxin Contamination Database, and China Agricultural Products Toxigenic Fungal Contamination Database 
1Co-First author

*Corresponding author

2015

Yueju Zhao1, Lancine Sangare1, Yao Wang, Yawa Minnie Elodie Folly, Huimin Song, Fuguo Xing, Lu Zhou, Yan Wang, Yang Liu*. Complete genome sequence of Bacillus subtilis SG6 antagonistic against Fusarium graminearum. Journal of Biotechnology, 2015, 194:10-11. IF: 2.884
Jonathan Nimal Selvaraj, Yueju Zhao, Lancine Sangare, Fuguo Xing, Lu Zhou, Yan Wang, Xiaofeng Xue, Yi Li, Yang Liu*. Limited survey of deoxynivalenol in wheat from different crop rotation fields wheat from Yangtze-Huaihe river basin region in China. Food control, 2015, Accepted. IF: 2.819
Fuguo Xing1, Wei Zhang1, Jonathan Nimal Selvaraj, Yang Liu*. DNA degradation in genetically modified rice with Cry1Ab by food processing methods: Implications for the quantification of genetically modified organisms. Food Chemistry, 2015, 174: 132-138. IF: 3.259
Jonathan Nimal Selvaraj, Yan Wang, Lu Zhou, Yueju Zhao, Fuguo Xing, Yang Liu*. A review of recent mycotoxin survey data and advanced mycotoxin detection techniques reported from China. Journal of Food Additives and Contaminants, Part A, 2015. IF: 0.914

2014

Yueju Zhao, Lancine Sangare, Yao Wang, Yawa Minnie Elodie Folly, Huimin Song, Fuguo Xing, Lu Zhou, Yan Wang, Yang Liu*. Complete genome sequence of Bacillus subtilis SG6 antagonistic against Fusarium graminearum. Journal of Biotechnology, 2014, Accepted. IF: 2.884
Lu Zhou1, Dan-Dan Wei1, Jonathan Nimal Selvaraj, Bo Shang, Chu-Shu Zhang, Fu-Guo Xing, Yue-Ju Zhao, Yan Wang and Yang Liu*. A strain of Aspergillus flavus from China shows potential as a biocontrol agent for aflatoxin contamination. Bicontrol Science and Technology, 2014, Accepted. IF: 0.731
Weihua Hu, Yingshuai Liu, Tao Chen, Yang Liu*, Chang Ming Li*. Hybrid ZnO Nanorod-Polymer Brush Hierarchically Nanostructured Substrate for Sensitive Antibody Microarrays. Advanced Material, 2014, doi: 10.1002/adma.201403712. IF: 15.409
Haiyu Luo, Hongwei Liu, Yuheng Cao, Dan Xu, Ziling Mao, Yan Mou, Jiajia Meng, Daowan Lai, Yang Liu and Ligang Zhou. Enhanced Production of Botrallin and TMC-264 with in Situ Macroporous Resin Adsorption in Mycelial Liquid Culture of the Endophytic Fungus Hyalodendriella sp. Ponipodef12. Molecules, 2014, 19(9), 14221-14234. IF: 2.638
Huijuan Hua1, Fuguo Xing1, Jonathan Nimal Selvaraj, Yan Wang, Yueju Zhao, Lu Zhou, Xiao Liu, Yang Liu*,Inhibitory Effect of Essential Oils on Aspergillus ochraceus Growth and Ochratoxin A Production. PLoS ONE, 2014, Accepted. IF: 3.73
Lancine Sangare1, Yueju Zhao1, Yawa Minnie Elodie Folly, Jinghua Chang, Jinhan Li, Jonathan Nimal Selvaraj, Fuguo Xing, Lu Zhou, Yan Wang, Yang Liu*. Aflatoxin B1 degradation by a Pseudomonas Strain. Toxins, 2014, Accepted. IF: 2.48
Weihua Hu, Hongming Chen, Huanhuan Zhang, Guangli He, Xin Li, Xiaoxing  Zhang, Yang Liu*, Chang Ming Li*. Sensitive detection of multiple mycotoxins by SPRi with gold nanoparticles as signal amplification tags. Journal of Colloid and Interface Science, 2014, 431: 71-76. IF: 3.172
Fuguo Xing, Huijuan Hua, Jonathan Nimal Selvaraj, Yueju Zhao, Lu Zhou, Xiao Liu, Yang Liu*. Growth inhibition and morphological alterations of Fusarium verticillioides by cinnamon oil and cinnamaldehyde. Food Control, 2014, 46:343-350. IF:2.738
Lu Shiqiong, Tian Jin, Sun Weibo, Meng Jiajia, Wang Xiaohan, Fu Xiaoxiang, Wang  Ali, Lai Daowan, Liu Yang*, Zhou Ligang*. Bis-naphtho-γ-pyrones from Fungi and Their Bioactivities. Molecules, 2014, 19(6): 7169-7188. IF: 2.428
Dandan Wei, Lu Zhou, Jonathan Nimal Selvaraj, Chushu Zhang, Fuguo Xing, Yueju Zhao, Yan Wang, Yang Liu*. Molecular characterization of atoxigenic Aspergillus flavus isolates collected in China. Journal of Microbiology, 2014, Doi:  10.1007/s12275-014-3629-8. IF: 1.276
Wei Zhang, Fuguo Xing, Jonathan Nimal Selvaraj, Yang Liu*. Comparison of DNA extraction methods for GM rice and GM rice-derived food products. Journal of Food Biochemistry, 2014, Doi: 10.1111/jfbc.12065. IF: 0.756
Wei Zhang, Fuguo Xing, Jonathan Nimal Selvaraj, Yang Liu*. Degradation of endogenous and exogenous genes of genetically modified rice with Cry1Ab during food processing. Journal of Food Science, 2014, 79 (5): T1055 -T1065. IF: 1.775
Yueju Zhao, Jonathan Nimal Selvaraj, Fuguo Xing, Lu Zhou, Yan Wang, Huimin Song, Xinxin Tan, Lichao Sun, Yang Liu*. Antagonistic Action of Bacillus subtilis Strain SG6 on Fusarium graminearum. PLoS ONE, 2014, 9(3): e92486. IF: 3.73
Fuguo Xing, Huijuan Hua, Jonathan Nimal Selvaraj, Yuan Yuan, Yueju Zhao, Lu Zhou, Yang Liu*. Degradation of fumonisin B1 by cinnamon essential oil. Food Control, 2014, 38: 37-40. IF: 2.738
Jonathan Nimal Selvaraj, Yang Liu*. Mycotoxin Detection-Recent trends at global level. Journal of Integrative Agriculture, 2014. IF: 0.625

2013

Weihua Hu, Guangli He,Tao Chen,Chun Xian Guo, Zhisong Lu, Jonathan Nimal Selvaraj, Yang Liu*, Chang Ming Li*, Graphene oxide-enabled tandem signal amplification for sensitive SPRi immunoassay in serum, Chemical Communications, 2013, Doi:10.1039/C3CC47933A. IF: 6.378
XiaoFeng Xue, Jonathan Nimal Selvaraj, Liuwei Zhao, Haimin Dong, Fengmao Liu, Yang Liu*, Yi Li. Simultaneous Determination of Aflatoxins and Ochratoxin A in Bee Pollen by Low-Temperature Fat Precipitation and Immunoaffinity Column Cleanup Coupled with LC-MS/MS. Food Analytical Methods, 2013, Doi: 10.1007/s12161-013-9723-4. IF: 1.969
Chu-Shu Zhang, Fu-Guo Xing, Jonathan Nimal Selvaraj, Qing-Li Yang, Lu Zhou, Yue-Ju Zhao, Yang Liu*. The effectiveness of ISSR profiling for studying genetic diversity of Aspergillus flavus from peanut-cropped soils in China. Biochemical Systematics and Ecology, 2013, 50: 147-153. IF: 1.153

2012

Li Cui, Jonathan Nimal Selvaraj, Fuguo Xing, Yueju Zhao, Lu Zhou, Yang Liu*. A minor survey of deoxynivalenol in Fusarium infected wheat from Yangtze-Huaihe river basin region in China. Food Control, 2012, 30: 469-473. IF: 2.738

2009

Fuguo Xing, Xungang Tan, Pei-Jun Zhang, Yang Liu, Junkai Ma. Cloning and characterization of NM23-Bbt2 gene from amphioxus Branchiostoma belcheri tsingtauense. Biologia, 2009, 64/4: 803-810. IF: 0.506

2006

Yang Liu, Kang Z, Buchenauer H. Ultrastructural and immunocytochemical studies on effects of Barley yellow dwarf virus-infection on Fusarium head blight, caused by Fusarium graminearum, in wheat plants. Journal of Phytopathology, 2006, 154(1): 6-15. IF: 1.0

2005

Yang Liu, Walker F, Hoeglinger B, Buchenauer H. Solvolysis procedures for the determination of bound residues of the mycotoxin deoxynivalenol in fusarium species infected grain of two winter wheat cultivars preinfected with barley yellow dwarf virus. Journal of Agricultural and Food Chemistry, 2005, 53(17): 6864-6869. IF: 2.906
Yang Liu, Buchenauer H. Effect of infections with Barley yellow dwarf virus and Fusarium spp. on assimilation of 14CO2 by flag leaves and translocation of photosynthates in wheat. Journal of Plant Diseases and Protection, 2005, 112(6):529-543. IF: 0.605
Yang Liu, Heinrich Buchenauer. Interactions between Barley yellow dwarf virus and Fusarium spp. Affecting development of Fusarium head blight of wheat. European Journal of Plant Pathology , 2005,113: 283-295. IF: 1.610

2002

Yang Liu, Buchenauer H. Interactions of Barley yellow dwarf virus and Fusarium head blight in winter wheat. Mitt Biol Bundesanst Land- Forstwirtschaft, 2002, 390: 184-185.

 
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